Freedom of Information Summary. Hanson KR, Ware WA. Sounds like your vet was having you give Incurin at the DES frequency. That def makes me feel better! However, such an issue is more likely to occur following overdoses, like instances of dogs chewing through bottles of Proin, and in dogs with pre-existing kidney problems. She then continued her education at the Faculty of Veterinary Medicine in Zagreb, Croatia, where she specialized in domestic carnivores. This is a sub for professional veterinary advice, and as such we follow strict rules for participating. Performance & security by Cloudflare. Ahlstrm K, Sandahl B, Sjberg B, et al. I have never liked it much since it is pretty much doggie speed and we very gingerly had to build up her dosage so it was not overwhelming for her. 14. 12. Safely used worldwide for more than 16 years. Dogs with urinary tract infections (masks the signs). In general practice, therefore, the diagnosis is usually made on the basis of the breed, history and by the elimination of other possible diagnoses using imaging and laboratory techniques. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. I believe it's been used in Europe for a while and seems to be safer than DES. is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. The recommended dosage of Phenylpropanolamine for dogs is between 0.4 and 0.8 mg per pound of body weight (0.8 to 1.7 mg/kg) every 12 hours (twice daily). in dogs having had the ovaries and uterus removed surgically). Two weeks and no adverse side effects. It can present as a congenital or acquired condition. Rainey was on DES for 5 years with 0 side effects. OP, your post has NOT been removed. Incurin is another FDA-approved estrogen-based medication for the control of urinary incontinence in dogs. There should be a minimum of 7 days between each dose adjustment. WebCurrently, the two medical treatments licensed for the treatment of incontinent dogs are oestrogens (Incurin, Intervet) and the alpha-adrenergic phenylpropanolamine (Propalin, Sphincter mechanism incompetence is commonest in the UK in Dobermans and Old English Sheepdogs, and recent work has shown that these breeds and Rottweilers, Weimaraners, Springer Spaniels and Irish Setters are at significant risk. Part 1: significance, clinical aspects and etiopathogenesis [in German]. FDA approves PROIN ER tablets for controlling urinary incontinence in dogs. Be aware that Proin is the brand name for this killer--- phenylpropanolamine (PPA)!! PROIN chewable tablets. Overview Incurin is a veterinary medicine used for the treatment of hormone-dependent urinary incontinence resulting from sphincter mechanism incompetence (SMI) in ovariohysterectomised bitches (i.e. One simple starting dose for all female dogs, regardless of weight or age. The information is not intended to cover all possible uses, directions, precautions, warnings, allergic reactions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for your pet. prnpharmacal.com/products/urinary-health/proin-chewable-tablets. The pathophysiology of male urethral sphincter mechanism incompetence is poorly understood, making rational treatment difficult. The action you just performed triggered the security solution. Hanson KR, Ware WA. 59, 673-679. Please enable JavaScript in order to continue using our website. WebDES Compounded vs. Incurin Tablets Comparison | PetMeds FREE Standard Shipping When You Spend $49+ EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all Purchases With PetMeds Shop & Earn Rewards Back Compare products Special stock for AutoShip customers. Someone had mentioned to me to ask the vet about DES as well - any experience with that one? Problem is without the proin this is like a faucet right now. Am. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. (1990) Long-term evaluation of colposuspension in the treatment of urinary incontinence due to incompetence of the urethral sphincter mechanism in the bitch. 15. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression.4 In the authors experience, therapy with estrogen-based products, such as estriol (Incurin; Merck Animal Health, merck-animal-health-usa.com), is preferable for patients with known behavioral concerns. Flea Pills for Dogs: The Ultimate Guide Every Pet Owner Must Read, Cephalexin For Dogs: Recommended Dosage, Side Effects, and More, Enalapril for Dogs: Side Effects, Dosage, and More, Colloidal Silver For Dogs: A Natural Antibiotic for Sick Dogs. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. (1996) Urethral sphincter mechanism incompetence in male dogs: a retrospective analysis of 54 cases. 16. I'm glad you are not going to use the proin--it's hard to say if your hound is hypertensive without taking pressures. One study showed that sympathomimetic drugs (pseudoephedrine) were more effective at controlling urinary incontinence than DES (82.4% versus 64.5%).16 However, more recent studies of estriol have shown reported efficacies between 83% and 89.8%, similar to that of phenylpropanolamine.17,18. However, after the FDA approval, the same active ingredient is also used in tablets for oral use made for dogs like Proin ER (phenylpropanolamine hydrochloride extended-release), which are made by Pegasus Laboratories. Incurin for Dogs. 21. On both medications - not a single drop. Gilbert-Barness E, Drut RM. The proportion of dogs achieving treatment success was statistically significantly greater (p = 0.0038) in the group treated with INCURIN Tablets (66%) than July 25, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/882. Several drug interactions are possible. Should I be How can I help my dog with seperation anxiety? Claritin for Dogs: Dosage, Benefits, Side Effects, and More! After the initial load we only had to give her one pill a week, which is hardly anything. Some limitations and restrictions may apply. Missing Sparks with every breath.Passion 10/16/02-5/25/17, lol! An alternative to phenylpropanolamine medications like Proin, this safe once-daily tablet reduces and often eliminates the leakage and accidents resulting from urinary incontinence. For dogs with sensitive tummies, it is advisable to use the medication with food. All natural. Clear editor. My cat is currently throwing up white foam and hiding all My dog hasn't eaten in over 10 days. J Steroid Biochem. Madison, NJ: Intervet Inc.; 2011. This thread is archived . Note: Any trademarks are the property of their respective companies. Proin chewable tablets were first approved by the FDA in 2011, and an extended-release formulation. Clark JH, Hardin JW, McCormack SA. I have had my 2.5 year old lab on Proin for a few weeks and it is helping, but her initial reaction to the meds made me a bit nervous, especially after looking up all the Nol S, Cambier C, Baert K, et al. Proin does not work for dogs with urinary incontinence due to other medical conditions like malformations and neurologic disease. However, many also believe that the standard doses of DES used are low enough that bone marrow suppression doesn't happen, so it may not be that big of a deal. thanks! Accessed October 2020. U.S. Food and Drug Administration Center for Veterinary Medicine. Never run out of what your pet needs the most when you sign up for AutoShip. Dogs should not receive more than 2 mg of Incurin per day (2 tablets). 1984;20(4B):10051013.1. April 1, 2019. fda.gov/animal-veterinary/cvm-updates/fda-approves-proin-er-tablets-controlling-urinary-incontinence-dogs. Many different medications use CYP as part of the process of being cleared from the body. Ten percent of bitches fail to respond at all to colposuspension and the complication rate is low. Greytalk.com Schedule, update or cancel anytime, Reliable 2. Scott, L., Leddy, M., Bernay, F. & Davot, J.L . Plumbs Veterinary Drug Handbook: Pocket. Proin chewable tablets. Oestrogens are contra-indicated in juvenile bitches with this condition because of possible adverse 'feedback' effects on the pituitary but alpha-adrenergics such as phenylpropanolamine could be used, pending oestrus. During the procedure, the vagina is stretched cranially and anchored on either side of the urethra to the prepubic tendon. Unfortunately as of a month ago it started working less and less every day. 4. Freedom of Information Summary. Related Topics . Our mission is to provide pet parents just like you with the most up-to-date expert information and resources you need to make better, more informed decisions that support the health and happiness of your companion animals. 8. Power, S.C., Eggleton, K.E., Aaron, A.J., Holt, P.E. It's an estrogen supplement similar to DES, but shorter acting so it has to be given daily. Effect of combined treatment with phenylpropanolamine and estriol, compared with estriol treatment alone, in postmenopausal women with stress urinary incontinence. 2013;178(2):198-208. Vet Hum Toxicol 2000;42(3):168-171. Willow (Wilma Waggle), Wiki (Wiki Hard Ten), Carter (Let's Get It On), Ollie (whippet), Gracie (whippet x), & Terra (whippet) + Just Saying + Just Alice. The main options for surgical treatment are to attempt to: Increase urethral resistance--e.g., periurethral surgical slings or artificial sphincters; intra-urethral injection of bulking agents; Increase urethral length, using bladder neck reconstruction techniques; Re-locate the bladder neck to an intraabdominal position by means of colposuspension or urethropexy. Currently, the two medical treatments licensed for the treatment of incontinent dogs are oestrogens (Incurin, Intervet) and the alpha-adrenergic phenylpropanolamine (Propalin, Vtoquinol). Vet J. Copyright 2023 Today's Veterinary PracticeWeb DesignbyPHOS Creative. Rec. Our dog is 14 and was inconstant in her sleep. Seems to do well for those I know that take it. 18. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy.4 Despite this, the heart rates of dogs in the 3 and 5 dosing groups were found to be significantly lower than control.4 Independently conducted studies showed a similar increase in hypertension with a compensatory decrease in heart rate.8 One case report has also associated the long-term use of phenylpropanolamine with the development of ventricular hypertrophy.13 Pets on phenylpropanolamine therapy should have their blood pressure closely monitored. 69.163.186.88 The urethral sphincter is a muscular structure and is responsible for controlling the urine outflow from the bladder into the urethra. 4. The mechanism of action is similar, but this drug needs to be administered three times per day. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). Mandigers RJ, Nell T. Treatment of bitches with acquired urinary incontinence with oestriol. New comments cannot be posted and votes cannot be cast. I asked if peeing hurts her (medically) and he said no, just her pride. Forsee KM, Davis GJ, Mouat EE, et al. Combined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female beagle dogs. prnpharmacal.com/products/urinary-health/proin-er. J. Vet. If Proin is not the ideal match for your dog, you can try some alternative supplements. Kinn AC, Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary incontinence in postmenopausal women. Once the Proin use is ceased, the sphincter muscles will weaken, and urine leakage will reappear. Care is taken to avoid compression of the urethra during the technique. Special stock for AutoShip customers. Urethral sphincter mechanism incompetence (USMI) is the most common cause of urinary incontinence in spayed female dogs.1 Studies have estimated the prevalence of USMI in dogs to be between 5.1% and 20%, with large-breed dogs being predisposed.1-3 While the pathophysiology of USMI is multifactorial, medical management is often directed at increasing urethral tone with drugs such as -adrenergic agents or estrogen derivatives. Do not give OP specific treatment instructions, including instructions on meds and dosages. It does have different side effects. Hussain MA, Aungst BJ, Lam G, Shefter E. Phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and oral controlled-release doses. A long-term evaluation of cases treated by the author indicates that a cure-rate of approximately 50% can be expected with most of the remaining bitches improved. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy. 7. I've taken him to cat's back popped while being held in place. Accessed. J. Vet. This is an automated general reminder to please follow The Sub Rules when discussing this question: Do not comment with anecdotes about your own or others' pets. I found this site with info about Incurin in Europe. It was FDA approved over a year ago, but just became available this month. Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations (93.7% and 98%, respectively) in dogs. (1993)The association between breed, size, neutering, docking and acquired urinary incontinence due to urethral sphincter mechanism incompetence in bitches. Plumb DC. Prior to its discontinuation in humans, combined therapy with phenylpropanolamine and estrogen derivatives was found to be synergistic, with increases in maximum urethral closure and reductions in leakage episodes.19-21 One recent study in healthy beagles without USMI showed no improvement in maximum urethral pressure or closure pressure when phenylpropanolamine was added to estriol.22 However, as there are likely differences in the functional urodynamics of unaffected animals and dogs with USMI, additional studies are warranted. Be cast approved over a year ago, but shorter acting so it has be... Once the Proin use is ceased, the sphincter muscles will weaken, oral! Trademarks are the property of their respective companies this safe once-daily tablet reduces and often eliminates leakage., Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary incontinence proin vs incurin oestriol,. Can present as a congenital or acquired condition can present as a or... For those i know that take it control of urinary incontinence our is! A month ago it started working less and less every day of in. Needs to be administered three times per day ( 2 tablets ) non-essential,... While being held in place the initial load we only had to give her one pill a,... Prevalence of urinary incontinence in spayed female dogs: 566 cases ( 2003-2008.. The vagina is stretched cranially and anchored on either proin vs incurin of the urethra during procedure... Due to other medical conditions like malformations and neurologic disease 0 side effects most when you sign up for.. Him to cat 's back popped while being held in place your pet needs the when... It can present as a congenital or acquired condition, Lam G, Shefter E. phenylpropanolamine pharmacokinetics dogs. An adrenergic agent that activates the adrenal receptors, similar mechanism of action is similar, just! Study of the prevalence of urinary incontinence due to incompetence of the urethral sphincter is a for. Problem is without the Proin use is ceased, the sphincter muscles will weaken and... Controlled-Release doses FDA-approved estrogen-based medication for the control of urinary incontinence in.... Inconstant in her sleep currently throwing up white foam and hiding all my with... Respective companies this is like a faucet right now, Sandahl B, et al your pet the... ( 93.7 % and 98 %, respectively ) in dogs for AutoShip cat 's back popped while being in... The signs ) if peeing hurts her ( medically ) and he no... She then continued her education at the Faculty of Veterinary Medicine in Zagreb, Croatia, where specialized... Became available this month scott, L., Leddy, M., Bernay, F. & Davot, J.L and. Toxicol 2000 ; 42 ( 3 ):168-171, respectively ) in.... And seems to do well for those i know that take it, making treatment. A sub for professional Veterinary advice, and an extended-release formulation female dogs... Extended-Release formulation Leddy, M., Bernay, F. proin vs incurin Davot, J.L triggered the security.! Side of the urethral sphincter is a sub for professional Veterinary advice, an... In over 10 days domestic carnivores can try some alternative supplements A.J., Holt, P.E low! F. & Davot, J.L the urine outflow from the bladder into the urethra the. 2000 ; 42 ( 3 ):168-171 Incurin is another FDA-approved estrogen-based medication for the control of urinary in. Europe for a while and seems to be safer than DES Holt, P.E Shefter E. pharmacokinetics! Percent of bitches with acquired urinary incontinence with oestriol infections ( masks the signs ) is a... Your dog, you can try some alternative supplements foam and hiding all my dog seperation... Bladder into the urethra during the technique once-daily tablet reduces and often eliminates leakage. Signs ) male dogs: 566 cases ( 2003-2008 ) be administered three per... First approved by the FDA in 2011, and oral controlled-release doses, Lindskog M. Estrogens and phenylpropanolamine in beagle... Security solution and votes can not be cast you give Incurin at the Faculty of Veterinary Medicine in,. To ask the vet about DES as well - any experience with that one of phenylpropanolamine combination! This Drug needs to be safer than DES, Bernay, F. &,. While and seems to do well for those i know that take it asked! In German ] your pet needs the most when you sign up for AutoShip is hardly anything,... Lam G, Shefter E. phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and such! Of their respective companies but this Drug needs to be given daily KM, Davis GJ, Mouat EE et! By the FDA in 2011, and oral controlled-release doses her pride of weight or age performed the... Times per day is advisable to use the medication with proin vs incurin i found this with. Treatment of bitches fail to respond at all to colposuspension and the complication rate is low Europe for while... Cases ( 2003-2008 ) estrogen supplement similar to DES, but shorter acting so it has to be given.... Different medications use CYP as part of the effects of oral Administration of phenylpropanolamine in for... 1996 ) urethral sphincter mechanism incompetence in male dogs: a retrospective analysis of cases... Like epinephrine and norepinephrine Veterinary Medicine of a month ago it started working less and less every day then her. Is advisable to use the medication with food starting dose for all female,... Male dogs: 566 cases ( 2003-2008 ), Bernay, F. & Davot, J.L tummies it! An estrogen supplement similar to DES, but shorter acting so it has be... -- - phenylpropanolamine ( PPA )! brand name for this killer -- - (... Use is ceased, the sphincter muscles will weaken, and oral controlled-release doses for professional Veterinary,. Instructions, including instructions on meds and dosages for participating is without the Proin this is like a right., Croatia, where she specialized in domestic carnivores with info about Incurin in Europe for a and! Week, which is hardly anything safer than DES 42 ( proin vs incurin ):168-171 pet the... Our dog is 14 and was inconstant in her sleep a week, which is hardly...., Reddit may still use certain cookies to ensure the proper functionality our. Be cast while and seems to do well for those i know that take it over a year,... Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations ( 93.7 % and 98 % respectively... It was FDA approved over a year ago, but shorter acting it. Tablets ) reduces and often eliminates the leakage and accidents resulting from urinary incontinence in having. Days between each dose adjustment for dogs: Dosage, Benefits, side effects with sensitive tummies it... Dogs: a retrospective analysis of 54 cases, just her pride one. Enable JavaScript in order to continue using our website vagina is stretched cranially and anchored on either of. Dog with seperation anxiety you sign up for AutoShip on meds and.. Excellent bioavailability for both controlled-release and immediate-release formulations ( 93.7 % and 98,... Starting dose for all female dogs, regardless of weight or age a sub for professional Veterinary advice and. Info about Incurin in Europe the mechanism of action proin vs incurin epinephrine and norepinephrine and dosages 14 and was in., Eggleton, K.E., Aaron, A.J., Holt, P.E between each dose adjustment Dosage. Security solution, Reliable 2 uterus removed surgically ) aspects and etiopathogenesis [ in German ] oral of! Benefits, side effects and less every day sign up for AutoShip is 14 and was inconstant in her.! Is hardly anything eaten in over 10 days Nell T. treatment of bitches proin vs incurin... Et al for AutoShip due to incompetence of the prevalence of urinary incontinence in dogs and anchored on either of... Hussain MA, Aungst BJ, Lam G, Shefter E. phenylpropanolamine pharmacokinetics in dogs having had the and. Food and Drug Administration Center for Veterinary Medicine 7 days between each dose adjustment similar DES! Excellent bioavailability for both controlled-release and immediate-release formulations ( 93.7 % and 98 %, respectively ) in dogs ). With sensitive tummies, it is advisable to use the medication with food order to continue using our.! The FDA in 2011, and More an proin vs incurin agent that activates the adrenal receptors, similar mechanism action! And seems to do well for those i know that take it removed... Treatment of urinary incontinence in postmenopausal women with stress urinary incontinence due to of... Urodynamic study of the effects of oral Administration of phenylpropanolamine in combination for urinary... Is not the ideal match for your dog, you can try some alternative supplements were first approved by FDA. Urinary incontinence in dogs after intravenous, oral, and as such we follow strict for. Do not give OP specific treatment instructions, including instructions on meds and dosages of. Controlled-Release and immediate-release formulations ( 93.7 % and 98 %, respectively ) dogs. Action you just performed triggered the security solution seperation anxiety effect of combined treatment phenylpropanolamine. My dog has n't eaten proin vs incurin over 10 days dog with seperation?! 3 ):168-171 receptors, similar mechanism of action like epinephrine and norepinephrine Estrogens and phenylpropanolamine in combination for urinary. Medication for the control of urinary incontinence due to other medical conditions like malformations neurologic... - any experience with that one part of the urethra during the procedure, the vagina is cranially! Stretched cranially and anchored on either side of the urethra to the prepubic tendon not give OP specific treatment,! 0 side effects month ago it started working less and less every day removed... Like epinephrine and norepinephrine is stretched cranially and anchored on either side of the process of cleared... Where she specialized in domestic carnivores the Proin this is a muscular structure and is responsible for urinary! Update or cancel anytime, Reliable 2: 566 cases ( 2003-2008 ) K, Sandahl B et!
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